The skeleton is a strong but bendable framework composed of 206 bones and their associated cartilages, connected by ligaments and muscles. It has 4 functions;
Osteoblasts are cells that convert soluble calcium chloride into insoluble calcium phosphate forming the basis of bone. This process is called ossification of which there are two types, intramembranous and intracartilaginous ossification. Intramembranous ossification occurs in the skull bones and is when the osteoblasts replace connective tissue with calcium phosphate. Intracartilaginous ossification occurs in the majority of the skeleton and is when the osteoblasts replace hyaline cartilage with calcium phosphate.
There are also cells called osteoclasts that function to absorb calcium phosphate. They work with the osetoblasts to remodel bone durng growth and throughout life. For example, in a long bone the osteoblasts originate in the tough outer covering of the cartilage called the periosteum and secrete bone onto the outer surface; simultaneously the osteoclasts remove bone from the inner surface, to create the medullary cavity and to prevent the bone becoming too thick and heavy.
Calcium, phosphorus and vitamins C and D are essential to bone growth. Major phases of bone growth occur before birth, as a child grows and when recovering from injury or bone disease. The effects of these nutrients are summarised in the table below;
Exercise also affects bone growth and repair as it increases blood supply to muscles and bones, stimulating growth. Muscles pulling on a bone will also affect the shape of a bone.
There are two types of bone tissue, compact and spongy;
Compact bone forms the outer surface of bones and consists of Harversian systems. Harversian systems are formed by tiny concentric plates of bone called lamellae which surround Harversian canals like the rings of a tree trunk. Each canal contains blood vessels, nerves and lymphatic vessels. In compact bone the lamellae and Haversian systems are packed closely together with only small spaces between the lamellae to house osteocytes and between each Harversian system for lymph.
Spongy bone fills the substance of bone and also consists of Haversian systems. Spongy bone differs from compact bone in that the Harversian canals are larger and there are larger gaps between the lamellae. The spaces this creates are filled with red and yellow bone marrow, which is a mixture of fat and red blood cells. The spaces also help to reduce the weight of the bone.
Bones can be classified in terms of their shape and have been divided into four categories; long, flat, irregular and short bones.
Long bones such as the femur and phalanges have a long shaft with two extremities; their main differences are associated with size. The shaft has an outer layer of compact bone with a hollow cavity called the medullary canal that contains yellow bone marrow for fat storage. Long bones are covered in periosteum and receive a rich blood supply.
Long bones develop from three areas; the first to ossify is the shaft and is called the diaphysis. There are then two secondary ossification centres at either end of the shaft called epiphyses, which develop after birth. From each centre of ossification, bone tissue gradually spreads through the cartilage until they meet. There remains a layer of epiphyseal cartilage between the diaphysis and the epiphyses that allows the shaft to continue growing until the age of 18 - 25. At this time the epiphyseal cartilage will ossify and the bone will stop growing.
Flat bones are plates formed by two layers of compact bone held together by spongy bone. Examples include the squamous bones of the skull, the scapula and the sternum. They are smooth and flat to protect delicate organs and provide attachment for muscles.
Irregular bones are a mass of spongy bone surrounded by compact bone. Examples include vertebrae, middle ear bones and the sphenoid bone of the skull.
Short bones are roughly cube-like and are approximately equal in all dimensions. Examples include the carpal and tarsal bones.
Bones display certain types of irregularities that are identified in the table below;